Acute Infectious Endophthalmitis After Cataract Surgery However, this is not the return of the original . Please enable it to take advantage of the complete set of features! Although cataract surgery is the most common surgical procedure performed on Medicare beneficiaries, serious postoperative complications such as endophthalmitis can still occur.1-3 Most data on postoperative endophthalmitis rates have been at the population level and have focused largely on patient-related risk factors for the occurrence of endophthalmitis.1,3 However, previous work . The https:// ensures that you are connecting to the Methods: 2015 Aug;122(8):1625-32. doi: 10.1016/j.ophtha.2015.04.036. Endophthalmitis after cataract surgery is usually the result of a bacterial infection. Risk factors that contribute to increased likelihood of vitreous loss include deep-set eyes, narrow palpebral fissures, high myopia, glaucoma, previous pars plana vitrectomy and a previous history of vitreous loss. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: Preliminary report of principal results from a European multicenter study, Wu PC, Li M, Chang SJ, Teng MC, Yow SG, et al. Attitudes and understanding of premium intraocular lenses in cataract Eye (Lond). Innovations are also ongoing to use intraocular lens for drug delivery and developing other intraocular drug delivery devices. Malaysia post-operative endophthalmitis (POE) was reported as low as 0.08%, and this could be a result of routine instillation of povidone-iodine before cataract surgery . Recent findings. (2006), ESCRS Endophthalmitis Study Group. AIM:To identify risk factors associated with post-cataract surgery endophthalmitis (PCE) in type 2 diabetic patients. Typically, postoperative endophthalmitis is caused by the perioperative introduction of microbial organisms into the eye either from the patient's normal conjunctival and skin flora . This site needs JavaScript to work properly. PMC Disclaimer. Will intracameral cefuroxime become the new standard in endophthalmitis prevention? Postoperative Endophthalmitis - Medscape Endophthalmitis after cataract surgery: epidemiology, risk factors, and evidence on protection Endophthalmitis prevention is at an interesting crossroad. Six databases were searched with no limits on the year or language of publication. The full texts of the remaining studies were then read to determine whether they met our inclusion criteria. Unauthorized use of these marks is strictly prohibited. Analysis of the retrospective studies showed PCR, a common complication of cataract surgery, was also a significant risk factor of acute endophthalmitis (OR 6.33, 95% CI 4.229.49). The site is secure. (1997), Risk of endophthalmitis after cataract extraction: results from the International Cataract Surgery Outcomes study, Javitt JC, Vitale S, Canner JK, Street DA, Krakauer H, et al. Patient characteristics were compared. 2022 Feb 18;15(2):327-335. doi: 10.18240/ijo.2022.02.20. Would you like email updates of new search results? Overall rates of endophthalmitis were calculated and grouped by patient demographics, surgical facility, season, year, and association with capsular rupture. Received 2013 Mar 16; Accepted 2013 Jul 1. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). (2012), Case control analyses of acute endophthalmitis after cataract surgery in South India associated with technique, patient care, and socioeconomic status, Keay L, Gower EW, Cassard SD, Tielsch JM, Schein OD (2012), Postcataract surgery endophthalmitis in the United States: analysis of the complete 2003 to 2004 Medicare database of cataract surgeries, Romero-Aroca P, Mndez-Marin I, Salvat-Serra M, Fernndez-Ballart J, Almena-Garcia M, et al. The https:// ensures that you are connecting to the A 10-year review of incidence and outcomes, Montan PG, Koranyi G, Setterquist HE, Stridh A, Philipson BT, et al. The magnitude of the ORs shown by our meta-analysis were inconsistent across studies while the pooled estimates were statistically significant for both without intracameral cefuroxime (OR 5.48, 95% CI 3.797.92) and without intracameral cefazolin (OR 10.76, 95% CI 6.4517.95) with no evidence of heterogeneity (I2=48.6%, P=0.083; I2=0%, P=0.858 respectively). Future work is required to address the higher rate of endophthalmitis in men, those with capsular rupture, and the oldest patients undergoing cataract surgery. Main body: Medical records of consecutive open globe injury patients admitted and primarily treated between January 2006 and December 2016 were retrospectively reviewed. anti-VEGF treatment Occurs most commonly as a complication of cataract surgery. This finding is supported by the results of the meta-analysis of the retrospective studies (OR 2.44, 95% CI 1.464.09) (Figure 5). Massachusetts Eye & Ear Infirmary, Harvard Medical School, United States of America. Bethesda, MD 20894, Web Policies The incidence following penetrating trauma is 4-13% and may be as high as 30% after injuries in rural settings. sharing sensitive information, make sure youre on a federal Epub 2015 Oct 21. A stable, self-sealing incision may be technically more difficult in the cornea than in the sclera. Can cataracts come back after surgery? - Medical News Today Risk factors for the development of endophthalmitis following cataract surgery include patient age, intraoperative surgical complications and poor wound construction. The search strategy used both keywords and Medical Subject Headings (MeSH) terms. Endophthalmitis (post-operative) (Exogenous endophthalmitis) A 10-year review of incidence and outcomes. An official website of the United States government. Estimates from three prospective cohort studies ( i.e., Pleyer U, Endophthalmitis Study Group, and Nagaki Y) [28], [31], [48] and from three retrospective studies (Al-Mezaine HS, Cooper BA, Lertsumitkol S) [25], [45], [51], were analyzed. 2022 Jun 8;10:913383. doi: 10.3389/fbioe.2022.913383. Methods: Risk factors. 8600 Rockville Pike FOIA METHODS:A hospital-based retrospective case-control study was conducted on 194 type 2 diabetic patients undergoing cataract surgery in Rajavithi Hospital from January 2007 to December 2015. 2022 Feb;129(2):129-138. doi: 10.1016/j.ophtha.2021.07.008. Therefore, potentially additional unpublished evidence regarding risk factors of acute endophthalmitis following cataract surgery during the past decade may be unavailable for analysis [4]. Lalitha P, Rajagopalan J, Prakash K, Ramasamy K, Prajna NV, Srinivasan M. Ophthalmology. Although small-incision phacoemulsification has remained the standard of care, surgeons continue to debate whether modifications in surgical technique have affected complication rates. Systemic risk factors include Marfan syndrome, morbid obesity, hypertension and diabetes. Epub 2012 Sep 12. After excluding this studies, the pooled OR was 2.37 (95% CI, 1.773.17) with no evidence of heterogeneity (I2=0%; P=0.41). 2023 Feb 1;6:1017420. doi: 10.3389/fdata.2023.1017420. However, Egger regression asymmetry test and the Begg's test suggested no evidence of publication bias in our study. Incidence of acute-onset postoperative endophthalmitis after cataract surgery. (2005), Postcataract endophthalmitis in South India incidence and outcome, West ES, Behrens A, McDonnell PJ, Tielsch JM, Schein OD (2005), The incidence of endophthalmitis after cataract surgery among the U.S. Medicare population increased between 1994 and 2001, Wallin T, Parker J, Jin Y, Kefalopoulos G, Olson RJ (2005), Cohort study of 27 cases of endophthalmitis at a single institution, Wejde G, Montan P, Lundstrm M, Stenevi U, Thorburn W (2005), Endophthalmitis following cataract surgery in Sweden: national prospective survey 19992001, Li J, Morlet N, Ng JQ, Semmens JB, Knuiman MW, et al. Dry Eye and Meibomian Gland Dysfunction in Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Injections. Epub 2015 Jun 2. Results: Study examines risk factors for endophthalmitis after cataract surgery Main outcome measures: All patients undergoing cataract surgery should be evaluated for any potential risk factors that can enhance the development of postoperative endophthalmitis; managing the intraoperative risk and prophylaxis protocols should be considered in order to reduce the risk of endophthalmitis. The European Society of Cataract and Refractive Surgeons (ESCRS) recommends surgeons to instill 5-10% of povidone iodine to the cornea and conjunctival sac for at least 3 . Cefuroxime or cefazolin is usually effective against the broad spectrum of bacteria causing acute onset postoperative endophthalmitis. Conclusions: The incidence of endophthalmitis decreased for extracapsular extraction over the whole period, but not for phacoemulsification over the recent 12 years. 2021 Nov;69(11):3329-3334. doi: 10.4103/ijo.IJO_1485_21. 10.1371/journal.pone.0071731 Abstract Background: Several risk factors for acute postoperative endophthalmitis (POE) following cataract surgery have been reported but the level of evidence and strength of association is varied. Endophthalmitis after Cataract Surgery in the United States: A Report Careers. Unable to load your collection due to an error, Unable to load your delegates due to an error. Barreau G, Mounier M, Marin B, Adenis JP, Robert PY. Endophthalmitis following inpatient surgery, Tordoff JM, Bagge ML, Gray AR, Campbell AJ, Norris PT (2010), Medicine-taking practices in community dwelling people aged 75 years in New Zealand, Upper lid skin bacterial count of surgical eye patients in Ibadan, Nigeria, Clark A, Morlet N, Ng JQ, Preen DB, Semmens JB (2011), Whole population trends in complications of cataract surgery over 22 years in Western Australia, Ravindran RD, Venkatesh R, Chang DF, Sengupta S, Gyatsho J, et al. This site needs JavaScript to work properly. A 2-sided P value less than 0.05 was regarded as significant for all analyses. (2003), A 10 year retrospective survey of cataract surgery and endophthalmitis in a single eye unit: injectable lenses lower the incidence of endophthalmitis. Clipboard, Search History, and several other advanced features are temporarily unavailable. Industry has started manufacturing formulations for commercial availability of intracameral injection. Our pooled analysis of six studies confirmed the increased risks of acute POE associated with ECCE/ICCE compared with phacoemulsification surgery from both developed and developing countries. . Available at: Higgins JP, Thompson SG, Deeks JD, Altman DG (2003), Quantifying heterogeneity in meta-analysis. Cataract surgery and intravitreal injections are the leading causes of endophthalmitis presently. eCollection 2021. In this Seminar, we discuss the pathophysiology and classification, epidemiology, risk and protective factors, symptoms, management, complications, outcomes, controversies, and future research questions of cataracts. Incidence of endophthalmitis after phacoemulsification cataract surgery: a Meta-analysis. The overall OR with the cross sectional study supported this finding (OR 5.48, 95% CI 3.797.92) (Figure 7). Endophthalmitis after cataract surgery: epidemiology, risk f - LWW Risk Factors for Developing Endophthalmitis After Cataract Surgery Br J Ophthalmol. As a library, NLM provides access to scientific literature. 2022 Jun 29;52(3):157-161. doi: 10.4274/tjo.galenos.2021.66168. eCollection 2023. Results Full-text articles were then obtained based on the initial screening of abstracts and the data extraction form was completed. A total of 6 686 169 participants with 8 963 endophthalmitis in 42 studies were analyzed. Would you like email updates of new search results? 2021 Oct 22;9:e12305. In all proven and unproven cases, the patients had swollen lids, pain and an opaque vitreous. Federal government websites often end in .gov or .mil. (1998), Intraocular lens implants and risk of endophthalmitis, Norregaard JC, Thoning H, Bernth-Petersen P, Andersen TF, Javitt JC, et al. government site. In a setting with phacoemulsification as the standard method, a selection bias for ECCE/ICCE in particularly difficult cases, e.g.
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